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It demonstrates linear kinetics over its usual dosage range and reaches peak plasma level approximately two hours after an oral dose.11 The elimination half-life is 20 to 40 hours, so a steady state is reached in approximately five days.

Mirtazapine is metabolized in the liver via the P450 cytochrome oxidase pathway, inhibiting cytochromes 2D6, 1A2 and 3A4. Clearance of the drug is diminished in the presence of liver or renal impairment.

Im having some serious issues sleeping atm, after finishing a gbl withdrawal and then doing stims at the tail end of it (bad idea, triggered mild psychosis) been a few days but ive barely slept an hour, i have a few mirtazapine about, should i take 15 or 30mg?

thanks You people obviously know nothing about Mirtazapine.

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Therefore, a lower dosage is recommended in elderly patients and those with liver or renal dysfunction.

Mirtazapine is also a good choice in depressed patients with significant anxiety or insomnia. Cost to the patient will be higher, depending on prescription filling fee*—Estimated cost to the pharmacist based on average wholesale prices, for one month's therapy at the lowest usual dosage level, in Red book. Selective serotonin reuptake inhibitors (SSRIs) have become the drugs of choice in the treatment of depression.3 Generally, either the older tricyclic antidepressants or the newer antidepressants are used for second-line therapy.4 During the first few years of introduction to the U. market, it is reasonable for an antidepressant such as mirtazapine to be reserved for use in patients who do not tolerate or do not respond to initial therapy with SSRIs.

And secondly; It is like a theatre screen playing in my head whilst I sleep.

The most vivid and believable dreams I have had in my entire life.

I used to be on remeron aswell, and I could take 45mg and still feel the sedating effects.

Sounds a bit to me like you are the one who knows nothing about mirtazapine and jumps to conclusions as soon as you hear the word 'norepinephrine'.

I even look forward to falling asleep now as it is so entertaining.

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